INDIANAPOLIS — Eli Lilly and Co. and Walmart have announced a collaboration to expand access to direct-to-consumer pricing for Zepbound (tirzepatide) single-dose vials available through LillyDirect. Zepbound (ZEHP-bownd) vials will be offered for pick-up at Walmart pharmacies nationwide by mid-November. LillyDirect’s direct-to-consumer pricing, or self-pay pricing, offers a 50% or greater discount compared to the list price of other incretin (GLP-1) medicines for obesity.
Zepbound single-dose vials will be available in all approved strengths, with the lowest dose starting at $349 per month with self-pay. Patients with a valid, on-label prescription can access Zepbound vials directly without using insurance. The collaboration with Walmart expands convenient access to Zepbound, especially for those who prefer the ease of pickup at their local Walmart pharmacy.
Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off, moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.
Convenience and Access
“Managing a chronic disease like obesity can be a significant and ongoing burden—physically, emotionally, and financially,” said Jennifer Mazur, SVP and General Manager of LillyDirect. “This collaboration with Walmart is designed to reduce that burden by streamlining access to prescribed treatment. By combining LillyDirect’s innovative, patient-centered platform with Walmart’s nationwide pharmacy footprint, we’re expanding options for patients facing access challenges, making it easier to start and stay on authentic Lilly medicine.”
Walmart’s team of over 50,000 trusted pharmacists and pharmacy technicians, and extensive pharmacy footprint, paired with LillyDirect’s online convenience, offers patients flexibility in how they access their medications and pharmacy support services. As the first retail collaboration for LillyDirect, this initiative marks a significant milestone—enhancing convenience, broadening access, and empowering patients with more choice in managing their treatment through both digital and in-person pharmacy experiences.
Pricing and Availability
“Life is busy, and this will help people discover new, easy ways to get their medication,” said Kevin Host, senior vice president of Pharmacy at Walmart. “We are known for building great relationships with our patients, and our teams look forward to doing more of that through making this pickup option available from our trusted pharmacists and pharmacy technicians.”
Customers initiating or continuing therapy with Zepbound can have their prescriptions routed directly to LillyDirect Self Pay Pharmacy Solutions through their health care provider’s electronic health record system and then choose the option that best fits their lives during the check-out process: free home delivery from LillyDirect or convenient local pick-up at Walmart Pharmacy. The price for Zepbound single-dose vials is the same for both LillyDirect options.
- $349 per month for the 2.5 mg recommended starting dose
- $499 per month for all other doses (5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg) To access the $499 monthly price for doses higher than 5 mg, patients must meet the requirements for the Zepbound Self Pay Journey Program, which is designed to support continuity of care and access, subject to applicable terms and conditions.
These prices are available to anyone with a valid, on-label Zepbound prescription, regardless of insurance status.
Growth and Expansion Continues
In the second quarter of 2025, LillyDirect’s self-pay option experienced rapid growth with approximately 35% of new Zepbound prescriptions fulfilled through LillyDirect. Lilly will continue to explore additional options to broaden patient access to authentic Lilly medicines.
“The growth of LillyDirect’s direct-to-consumer offering underscores the momentum behind a more modern, consumer-driven model of care,” said Mazur. “LillyDirect, powered by Walmart, builds on that progress — extending convenience and choice to patients while reinforcing LillyDirect’s mission to empower more people on their health journey.”
