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North America leads rapidly growing GLP-1 market

The US drives growth via branded therapies, rising obesity, and broader use in diabetes and weight management.

SAMBALPUR, India — The global market for GLP-1 receptor agonists is expected to more than double by the end of the decade, as demand for obesity, diabetes, and cardiometabolic treatments accelerates, according to a new Strategic Market Research report.

The research firm estimates the market will grow from $18.4 billion in 2024 to $41.5 billion by 2030, a compound annual growth rate of 12.3%.

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Once primarily prescribed for blood glucose control in patients with Type 2 diabetes, GLP-1 receptor agonists have become one of the pharmaceutical industry's fastest-growing therapeutic categories. The report notes that these drugs are increasingly used to treat obesity, reduce cardiovascular risk, address sleep-related metabolic conditions, and support long-term chronic disease management.

Strategic Market Research said that rising rates of obesity and diabetes worldwide are fueling demand for therapies that address multiple metabolic risk factors simultaneously. As a result, GLP-1 medications are being evaluated not only for their clinical effectiveness but also for their potential to reduce long-term healthcare costs associated with obesity and diabetes-related complications.

Injectable GLP-1 therapies remain the dominant segment, accounting for approximately 82% of global revenue in 2024, or $15.1 billion. Their market leadership is supported by established physician familiarity, broad adoption across diabetes and obesity treatment pathways, and the convenience of once-weekly dosing.

However, oral GLP-1 therapies are expected to be among the market’s most significant growth drivers through 2030. Valued at approximately $3.3 billion in 2024, oral formulations could help expand use among patients reluctant to use injections and support broader adoption in primary care settings.

Type 2 diabetes remains the largest indication for GLP-1 therapies, generating approximately $12.5 billion in revenue and accounting for 68% of the global market in 2024. Obesity and weight management represented an estimated $5.9 billion and are expected to be the fastest-growing indication, as healthcare providers increasingly view obesity as a chronic disease requiring long-term treatment.

North America accounted for the largest regional share of the market in 2024, representing roughly 70% of global revenue, or $12.9 billion. The United States continues to drive growth through strong uptake of branded therapies, rising obesity prevalence, and broader use among diabetes and weight-management populations.

Retail pharmacies remain the leading distribution channel, accounting for approximately $8.3 billion in sales and 45% of the market. The report also highlighted growing opportunities for online pharmacies as telehealth platforms, digital weight-management programs, and home-delivery prescription services gain traction.

Major companies competing in the GLP-1 market include Novo Nordisk, Eli Lilly, Pfizer, AstraZeneca, Sanofi, Zealand Pharma, Amgen, and Innovent Biologics. Strategic Market Research said that future competition will increasingly focus on oral therapies, next-generation dual and triple agonists, cardiovascular outcomes data, manufacturing capacity, and payer access.

The report concludes that GLP-1 receptor agonists are rapidly evolving from diabetes treatments into a foundational platform for obesity care, cardiometabolic disease management, and chronic disease prevention, positioning the category for sustained growth through the rest of the decade.

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